Comparative Sequence Analysis
Module entry page
The module pages contain information and research tools on mobile protein domains, developed, collected and maintained by the Bork group and various collaborators
for details see:
Schultz,J., Milpetz,F., Bork,P. & Ponting,C.P. (1998).
SMART, a simple modular architecture research tool: Identification of signaling
domains. PNAS, 95, 5857-5864, Abstract, Full Text, PDF Download
You can subscribe to a domain and will get weekly reports on homologs of
this domain that have been newly entered into sequence databases
with a Nomenclature as used in the SWISS-PROT and PROSITE databases and presented in Bork, P. & Bairoch, A. (1995) TIBS 20(3), poster C02 "Extracellular protein modules: A proposed nomenclature"
For example, ca 90 signalling domains have been annotated in the entire yeast genome For a review on non-catalytic signalling domains see Ponting, C.P., Schultz, J. and Bork, P. (1997) TIBS 22 (8) poster C04 "The signalling domain repertoire"
Further helpful tools are our WU-blast2 server with an ortholog identification postprocessing and our sequence alerting system
Last modified Nov 15, 1997