The WW domain: a protein module that binds proline-rich or proline-containing ligands |
Groups/Representative proteins | Consensus sequence of the ligand | Representative ligands |
---|---|---|
Group I YAP65, Nedd4, Dystrophin |
PPxY | PEBP2 transcriptional activator, ENaC sodium channel, beta-dystroglycan |
Group II Formin Binding Proteins, FE65 |
PPPPPPL/RP | Formin, Mena, Bat2 |
Group III Formin Binding Proteins |
(PxxGMxPP)N | Splicing factors: SmB, SmB', U1C |
Group IV Ess1/Pin1 |
(Phospho-S/T)P | RNA Pol II, Cdc25C |
Group V Npw38/PQBP-1 |
Rx(x)PPGPPPxR | NpwBP |