Bork Group

The WW domain: a protein module that binds proline-rich or proline-containing ligands

EMBL

Classification of WW domains based on their ligand specificity

Groups/Representative proteins Consensus sequence of the ligand Representative ligands
Group I
YAP65, Nedd4, Dystrophin
PPxY PEBP2 transcriptional activator, ENaC sodium channel, beta-dystroglycan
Group II
Formin Binding Proteins, FE65
PPPPPPL/RP Formin, Mena, Bat2
Group III
Formin Binding Proteins
(PxxGMxPP)N Splicing factors: SmB, SmB', U1C
Group IV
Ess1/Pin1
(Phospho-S/T)P RNA Pol II, Cdc25C
Group V
Npw38/PQBP-1
Rx(x)PPGPPPxR NpwBP

Last modified May 25, 2000.