Bork Group

WW domains: automatically generated alignment,
updated through the Sequence Alerting System by SMART.

EMBL
S M A R T Simple Modular Architecture Research Tool      (V3.1)

ReferencesSchultz, J., Milpetz, F., Bork, P., and Ponting, C.P. (1998) SMART, a simple modular architecture research tool: Identification of signalling domains Proc. Natl. Acad. Sci. USA 95, 5857-5864
Schultz, J., Copley, R.R., Doerks, T., Ponting, C.P. and Bork, P. (2000) SMART: A Web-based tool for the study of genetically mobile domains Nucleic Acids Res 28, 231-234

Alignment of all members of the WW domain family defined by SMART.

Click on the name of the protein to see it's database entry, on the delimiters to see the SMART structure.
AAF26839/21-54        PLPPGWEIKIDPQTGWPFFVD..HNSRTTTWNDPRV
AAF26840/23-56        PLPPGWEIKIDPQTGWPFFVD..HNSRTTTWNDPRV
AAF27049/17-49        ELPPGWEERTTKD-GWVYYAN..HTEEKTQWEHPKT
        /58-90        DLPYGWEQETDEN-GQVFFVD..HINKRTTYLDPRL
AAF31693/17-49        ELPPGWEERTTKD-GWVYYAN..HTEEKTQWEHPKT
        /58-90        DLPYGWEQETDEN-GQVFFVD..HINKRTTYLDPRL
AAF31694/17-49        ELPPGWEERTTKD-GWVYYAN..HTEEKTQWEHPKT
        /58-90        DLPYGWEQETDEN-GQVFFVD..HINKRTTYLDPRL
AAF43897/6-39         KLPPGWEKRMSRSSGRVYYFN..HMTNASQWERPIA
AAF45194/382-414      PLPPGWEERTHTD-GRIFYIN..HNIKKTQWEDPRL
        /99-131       PLPPGWEERQDIL-GRTYYVN..HESRRTQWKRPTP
        /256-288      GLPPGWEEKQDER-GRSYYVD..HNSRTTTWTKPAV
        /330-362      FLPKGWEVRHAPN-GSPFFID..HNTKTTTWEDPRL
AAF59410/650-683      ATPKGWSCHWDRDHRRYFYVN..EQSGESQWEFPDG
        /265-298      IEMGDWQEVWDENTGCYYYWN..TQTNEVTWELPQY
AAF60344/680-712      DNNSKWVKHWVKG-GYHYYHN..LETQAGGWAEPPD
AAF60409/5-38         SLPAGWEKRQSRSNDRVYYFN..TATGRSQWERPDE
AAF60858/254-286      PLPQGWEMRRDPR-GRVYYVD..HNTRTTTWQRPTA
        /325-358      PLPEGWEKRQDPNTSRMYFVN..HVNRTTQWEDPRT
        /220-252      QLPDGWEMRFDQY-GRKYYVD..HTTKSTTWERPST
        /367-399      PLPDGWEMRFTEQ-GVPFFID..HQSKTTTYNDPRT
AAF65172/30-61        GLPPGWRKIHDAA--GTYYWH..VPSGSTQWQRPTW
AAF65174/30-61        GLPPGWRKIHDAA--GTYYWH..VPSGSTQWQRPTW
AAF65175/30-61        GLPPGWRKIHDAA--GTYYWH..VPSGSTQWQRPTW
CAB70754/343-375      FLPPGWEMRIAPN-GRPFFID..HNTKTTTWEDPRL
        /143-175      PLPPGWEEKVDNL-GRTYYVN..HNNRTTQWHRPSL
        /394-426      PLPPGWEERIHLD-GRTFYID..HNSKITQWEDPRL
CAB70761/592-625      ATPKGWSCHWDRDHRRYFYVN..EQSGESQWEFPDG
        /211-244      IEMGDWQEVWDENTGCYYYWN..TQTNEVTWELPQY
CAB70824/63-96        PLPPGWEIKIDPQTGWPFFVD..HNSRTTTWNDPRV
CAB71182/654-686      KLPPSWEEHFTND-GRRYFID..TATQTTTWKDPRF
CAB75796/509-542      PLPPGWEKRADAVTGKSYYID..HNTKTTTWSHPCP
CAB87628/16-49        NLPKPWKGLVDSRTGYLYFWN..PETNVTQYERPAS
O00213/254-285        DLPAGWMRVQDTS-GTYYWHI..-PTGTTQWEPPGR
O00307/161-193        TLPSGWEQRKDPH-GRTYYVD..HNTRTTTWERPQP
      /194-225        -LPPGWERRVDDR-RRVYYVD..HNTRTTTWQRPTM
      /268-300        PLPPGWEKRVDST-DRVYFVN..HNTKTTQWEDPRT
      /308-340        PLPEGWEIRYTRE-GVRYFVD..HNTRTTTFKDPRN
O00308/331-363        PLPPGWEKRTDPR-GRFYYVD..HNTRTTTWQRPTA
      /406-437        PLPPGWEKRQDNG--RVYYVN..HNTRTTQWEDPRT
      /445-477        ALPPGWEMKYTSE-GVRYFVD..HNTRTTTFKDPRP
      /301-330        ALPAGWEQRELPN-GRVYYVD..HNTKTTTWER---
O00309/150-182        PLPENWEMAYTEN-GEVYFID..HNTKTTSWLDPRC
O01264/175-207        PLPEGWTVISHQS-GMPVYYH..KFTRVVTHSKPYL
O08614/2810-2842      SVQLPWQRSISHN-KVPYYIN..HQTQTTCWDHPKM
O08758/140-172        PLPPGWEERQDVL-GRTYYVN..HESRRTQWKRPSP
      /296-328        GLPPGWEEKQDDR-GRSYYVD..HNSKTTTWSKPTM
      /351-383        PLPPGWEERTHTD-GRVFFIN..HNIKKTQWEDPRL
O13598/8-43           GLPNGWVAQWDERYKCYFYVNesDPKAKPQWECPVR
O14176/31-63          TVASDWHEVKTED-SRVYYYN..SVTRKSVWEKPEE
      /72-104         LSKLAWKEYATAD-GKKYWYN..VNTRESVWDIPDE
O14326/237-269        RLPPGWERRADSL-GRTYYVD..HNTRTTTWTRPAS
      /307-339        DLPFGWEMRYTDT-GRPYFVD..HNTRTTTWVDPRN
      /365-397        PLPSGWEMRLTNS-ARVYFVD..HNTKTTTWDDPRL
O14776/132-164        PTEEIWVENKTPD-GKVYYYN..ARTRESAWTKPDG
      /430-462        TAVSEWTEYKTAD-GKTYYYN..NRTLESTWEKPQE
      /529-561        IPGTPWCVVWTGD-ERVFFYN..PTTRLSMWDRPDD
O15036/786-818        PLPPNWEARIDSH-GRVFYVD..HVNRTTTWQRPTA
      /975-1007       ELPRGWEIKTDQQ-GKSFFVD..HNSRATTFIDPRI
O16786/90-123         PLPENWVEVYDEGLAKYYFWN..KTTDEVCWYSPRH
O22014/297-328        DLPPGWHVANDED-GDPYYYH..-DDGRNQWVRPGA
      /363-394        HLLPGWHVAYDEV-GDPYYYH..-DDGRSQWDAPLN
O35827/30-61          GLPPGWRKIRDAA--GTYYWH..VPSGSTQWQRPTW
O42573/191-223        PMPPGWEEKVDNL-GRTYYVN..HNNKSTQWQRPSL
      /382-414        GLPSGWEERKDAK-GRTYYVN..HNNRTTTWTRPIV
      /494-526        FLPPGWEMRIAPN-GRPFFID..HNTKTTTWEDPRL
      /545-577        PLPPGWEERIHMD-GRTFYID..HNTKITQWEDPRL
O42735/5-38           GLPAGWEVRHSNSKNLPYYFN..PATRESRWEPPAD
O43144/14-46          ILPPGWQSYLSPQ-GRRYYVN..TTTNETTWERPSS
O43165/234-266        PLPPGWEEKVDNL-GRTYYVN..HNNRTTQWHRPSL
      /406-438        GLPSGWEERKDAK-GRTYYVN..HNNRTTTWTRPIM
      /518-550        FLPPGWEMRIAPN-GRPFFID..HNTKTTTWEDPRL
      /569-601        PLPPGWEERIHLD-GRTFYID..HNSKITQWEDPRL
O43584/163-195        PLPPGWEQRVDQH-GRVYYVD..HVEKRTTWDRPEP
      /196-227        -LPPGWERRVDNM-GRIYYVD..HFTRTTTWQRPTL
      /275-307        PLPPGWEKRTDSN-GRVYFVN..HNTRITQWEDPRS
      /315-347        PLPEGWEMRFTVD-GIPYFVD..HNRRTTTYIDPRT
O43856/134-166        GAKSMWTEHKSPD-GRTYYYN..TETKQSTWEKPDD
      /175-207        LSKCPWKEYKSDS-GKPYYYN..SQTKESRWAKPKE
O43863/152-184        PLPENWEMAYTEN-GEVYFID..HNTKTTSWLDPRC
      /211-243        ELPAGWEKIEDPV-YGIYYVD..HINRKTQYENPVL
O54893/301-333        PLPENWEMAYTEN-GEVYFID..HNTKTTSWLDPRC
      /348-380        ELPAGWEKIEDPV-YGVYYVD..HINRKTQYENPVL
O54971/278-310        PLPPGWEQRVDQH-GRVYYVD..HVEKRTTWDRPEP
      /311-342        -LPPGWERRVDNM-GRIYYVD..HFTRTTTWQRPTL
      /390-422        PLPPGWEKRTDSN-GRVYFVN..HNTRITQWEDPRS
      /430-462        PLPEGWEMRFTVD-GIPYFVD..HNRRATTYIDPRT
O55147/2800-2832      SVQLPWQRSISHN-KVPYYIN..HQTQTTCWDHPKM
O55148/42-74          ILPPGWHSYLSPQ-GRRYYVN..TTTNETTWERPSS
O60045/8-41           GLPEDWEVRHSQSKNLPYYFN..SATKTSRWEPPSG
O60434/140-172        PLPDNWEMAYTEK-GEVYFID..HNTKTTSWLDPRL
      /186-218        ELPYGWEKIDDPI-YGTYYVD..HINRRTQFENPVL
O60510/303-335        PLPDNWEMAYTEK-GEVYFID..HNTKTTSWLDPRL
      /349-381        ELPYGWEKIDDPI-YGTYYVD..HINRRTQFENPVL
O60828/47-80          GLPPSWYKVFDPSCGLPYYWN..ADTDLVSWLSPHD
O62529/380-412        SVKPPWERATTAA-NVPYYID..HERQTTHWDHPEM
O64430/18-51          TLPKPWKGLIDDRTGYLYFWN..PETNVTQYEKPTP
O74448/5-38           GLPKPWIVKISRSRNRPYFFN..TETHESLWEPPAA
O75085/301-333        PLPENWEMAYTEN-GEVYFID..HNTKTTSWLDPRC
      /360-392        ELPAGWEKIEDPV-YGIYYVD..HINRKTQYENPVL
O75397/4-36           VLPPNWKTARDPE-GKIYYYH..VITRQTQWDPPTW
O75400/116-148        GAKSMWTEHKSPD-GRTYYYN..TETKQSTWEKPDD
      /157-189        LSKCPWKEYKSDS-GKPYYYN..SQTKESRWAKPKE
O75401/58-90          PPRALWSEHVAPD-GRIYYYN..ADDKQSVWEKPSV
      /99-131         LSQCPWKEYKSDT-GKPYYYN..NQSKESRWTRPKD
O75404/145-177        GAKSMWTEHKSPD-GRTYYYN..TETKQSTWEKPDD
      /186-218        LSKCPWKEYKSDS-GKPYYYN..SQTKESRWAKPKE
O75405/13-45          VLPPNWKTARDPE-GKIYYYH..VITRQTQWDPPTW
O75554/123-155        PSKGRWVEGITSE-GYHYYYD..LISGASQWEKPEG
      /164-196        AVKTVWVEGLSED-GFTYYYN..TETGESRWEKPDD
O75853/216-248        ELPEGYEQRTTVQ-GQVYFLH..TQTGVSTWHDPRI
      /262-294        PLPPGWEVRSTVS-GRIYFVD..HNNRTTQFTDPRL
O76976/186-218        SVQHPWERAVAAN-KVPYFIN..HGTETTHWDHPRM
O80682/193-226        TLPLGWVDAKDPASGATYYYN..QHTGTCQWERPVE
      /238-271        LSKEEWIETFDEASGHKYFYN..TRTHVSQWEPPAS
O88382/303-335        PLPDNWEMAYTEK-GEVYFID..HNTKTTSWLDPRL
      /349-381        ELPYGWEKIDDPI-YGTYYVD..HINRRTQFENPVL
O94060/11-44          QVPDGWVAKFDEEYSTWYYVD..LKTKKSQWDAPAG
O94425/9-44           GLPAGWVAQWDPTYQAYFYINetFEGAQPQWEPPIP
O94426/9-44           GLPSGWVAQWDAEYGTYFYVNesAQNPQPQWEPPVE
O97592/3051-3083      SVQGPWERAISPN-KVPYYIN..HETQTTCWDHPKM
P91152/1347-1379      KTKYVWAIAKSEA-GETYYYN..KITKETQWTAPTP
P91441/93-125         PLPENWAVEFTTE-NQPYYVD..HANRRTHWVHPFV
      /128-160        SLKPGWKKFFDPE-KGVFYYH..EEMKRTQYEHPGI
P97702/1-24           ---------VTAD-GHCYYYD..LVTGASQWEKPEG
      /33-65          AAKAIWVEGLSED-GYTYYYN..TXTGQSKMGKPDD
Q06525/1-32           -MRGEWQEFKTPA-GKKYYYN..KNTKQSRWEKPNL
Q09547/230-262        PPESHWKTYLDAK-KRKFYVN..HVTKETRWTKPDT
      /373-404        PLPSGWECITMNN--RTVFLN..HANKETSFYDPRI
Q13576/595-627        SSDGSWLKLNLHK-KYDYYYN..TDSKESSWVTPES
Q14205/3056-3088      SVQGPWERAISPN-KVPYYIN..HETQTTCWDHPKM
Q14670/525-558        TVNEPWTMGFSKSFKKKFFYN..KKTKDSTFDLPAD
Q19404/219-251        PMPQGWEMCYDSD-GVRYFKD..HNSKTTTWDDPRL
Q21075/132-164        LLPPNWETAYTEN-GDKYFID..HNTGTTTWDDPRE
Q23399/195-227        EGQELWVETETAE-GKKYFYH..PVNRNTIWERPQN
      /262-294        NPDDAWNEFNAPD-GRKYYFN..SITQENTWEKPKA
      /377-409        VSGTPWCVVWTGD-DKVFFYN..PSTKCSVWERPPD
Q23425/199-232        NVSPPWKAWWHTEKKRKFYTN..DKTKESLWDHPNT
Q60780/23-55          ILPPGWHSYLSPQ-GRRYYVN..TTTNETTWERPSS
Q61048/124-156        ASKGGWVEGVTAD-GHCYYYD..LITGASQWEKPEG
      /165-197        AAKAVWVEGLSED-GYTYYYN..TETGESKWEKPED
Q61049/1-28           -----WTEHKSPD-GRTYYYN..TETKQSTWEKPDD
      /37-67          LSKCPWKEYKSDS-GKPYYYN..SQTKESRWAKP--
Q61636/368-400        SVQLPWQRSISHN-KVPYYIN..HQTQTTCWDHPKM
Q62940/403-435        GLPPGWEEKQDDR-GRSYYVD..HNSKTTTWSKPTM
      /460-492        PLPPGWEERTHTD-GRVFFIN..HNIKKTQWEDPRM
      /247-279        PLPPGWEERQDVL-GRTYYVN..HESRTTQWKRPSP
Q91493/254-286        SVQGPWERAISPN-KVPYYIN..HQTQTTCWDHPKM
Q92870/263-294        DLPPGWKRVSDIA-GTYYWHI..-PTGTTQWERPVS
Q9WV89/501-533        CLPYGWEEAYTAD-GIKYFIN..HVTQTTSWIHPVM
Q9WVC9/93-125         PPRALWSEHVAPD-GRIYYYN..ADDKQSVWEKPSV
      /134-166        LSQCPWKEYKSDT-GKPYYYN..NQSQESRWTRPKD
Q9WVQ1/139-171        PLPDNWEMAYTEK-GEVYFID..HNTKTTSWLDPRL
      /185-217        ELPYGWEKIDDPI-YGTYYVD..HINRRTQFENPVL
Q9XW28/6-38           RTFAGWTEQMSSS-GKMYYYN..KKTEISQWDKPAE
Q9XZE9/667-699        SSWVGWTETRVPQ-GYTYYLN..VSSKEFRWSLPPN
Q9Y0H4/364-396        PLPAGWEIRLDQY-GRRYYVD..HNTRSTYWEKPTP
      /397-428        -LPPGWEIRKDGR-GRVYYVD..HNTRKTTWQRPNS
      /478-510        PLPDGWEKKIQSD-NRVYFVN..HKNRTTQWEDPRT
      /522-554        PLPPGWEIRYTAA-GERFFVD..HNTRRTTFEDPRP
Q9Y2L7/316-349        ATPKGWSCHWDRDHRRYFYVN..EQSGESQWEFPDG
FCA_ARATH/592-624     SVKCTWTEHTSPD-GFKYYYN..GLTGESKWEKPEE
PINL_HUMAN/6-39       KLPPGWEKRMSRPSGRGYYFN..HITNPSQWERPSG
PR40_YEAST/40-72      LRENGWKAAKTAD-GKVYYYN..PTTRETSWTIPAF
          /1-31       --MSIWKEAKDAS-GRIYYYN..TLTKKSTWEKPKE
DOD_DROME/6-39        QLPDGWEKRTSRSTGMSYYLN..MYTKESQWDQPTE
DMD_MOUSE/3049-3081   SVQGPWERAISPN-KVPYYIN..HETQTTCWDHPKM
DMD_HUMAN/3056-3088   SVQGPWERAISPN-KVPYYIN..HETQTTCWDHPKM
DMD_CHICK/3053-3085   SVQGPWERAISPN-KVPYYIN..HETQTTCWDHPKM
ESS1_YEAST/30-63      GLPTPWTVRYSKSKKREYFFN..PETKHSQWEEPEG
YO61_CAEEL/79-111     SVESDWSVHTNEK-GTPYYHN..RVTKQTSWIKPDV
          /124-156    PQQGQWKEFMSDD-GKPYYYN..TLTKKTQWVKPDG
RSP5_YEAST/230-262    RLPPGWERRTDNF-GRTYYVD..HNTRTTTWKRPTL
          /332-364    ELPSGWEQRFTPE-GRAYFVD..HNTRTTTWVDPRR
          /388-420    PLPSGWEMRLTNT-ARVYFVD..HNTKTTTWDDPRL
YFB0_YEAST/10-43      QVPSGWKAVFDDEYQTWYYVD..LSTNSSQWEPPRG
FE65_RAT/43-74        DLPAGWMRVQDTS-GTYYWHI..-PTGTTQWEPPGR
NED4_HUMAN/219-251    PLPPGWEERQDIL-GRTYYVN..HESRRTQWKRPTP
          /376-408    GLPPGWEEKQDER-GRSYYVD..HNSRTTTWTKPTV
          /449-481    FLPKGWEVRHAPN-GRPFFID..HNTKTTTWEDPRL
          /501-533    PLPPGWEERTHTD-GRIFYIN..HNIKRTQWEDPRL
NED4_MOUSE/320-352    PLPPGWEERQDVL-GRTYYVN..HESRRTQWKRPSP
          /476-508    GLPPGWEEKQDDR-GRSYYVD..HNSKTTTWSKPTM
          /531-563    PLPPGWEERTHTD-GRVFFIN..HNIKKTQWEDPRL
YA65_CHICK/170-202    PLPPGWEMAKTPS-GQRYFLN..HIDQTTTWQDPRK
YA65_HUMAN/172-204    PLPAGWEMAKTSS-GQRYFLN..HIDQTTTWQDPRK
YA65_MOUSE/157-189    PLPAGWEMAKTSS-GQRYFLN..HNDQTTTWQDPRK
          /216-248    PLPDGWEQAMTQD-GEVYYIN..HKNKTTSWLDPRL
UTRO_HUMAN/2813-2845  SVQLPWQRSISHN-KVPYYIN..HQTQTTCWDHPKM
IQGA_HUMAN/680-712    DNNSKWVKHWVKG-GYYYYHN..LETQEGGWDEPPN
YLE5_CAEEL/97-129     DLLNGWFEYETDV-GRTFFFN..KETGKSQWIPPRF
DB10_NICSY/19-52      TLPKPWKGLVDGTTGFIYFWN..PETNDTQYERPVP
YJQ8_YEAST/476-507    RLPPGW-EIIHEN-GRPLYYN..AEQKTKLHYPPSG
YA12_SCHPO/4-36       PLPPGWTEHKAPS-GIPYYWN..AELKKSTYQRPSF
          /90-122     PNNDSWVVVFTKK-NRYFFHN..LKSHESYWEPPLE
DRP2_HUMAN/350-382    SVQVPWERAISPN-KVPYYIN..HQAQTTCWDHPKM
PIN1_HUMAN/6-39       KLPPGWEKRMSRSSGRVYYFN..HITNASQWERPSG
PUB1_SCHPO/206-238    RLPPGWERRTDNL-GRTYYVD..HNTRSTTWIRPNL
          /289-321    ELPPGWEQRYTPE-GRPYFVD..HNTRTTTWVDPRR
          /346-378    PLPSGWEMRLTNT-ARVYFVD..HNTKTTTWDDPRL

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